Chemical carcinogens such as benzo[a]pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) may contribute to the etiology of human diet-associated
cancer. Individually, these are genotoxic, but the consequences of exposure to mixtures of these chemicals have not been systematically examined. The objective of the study was to determine the mutagenic response to mixtures of BaP and PhIP at concentrations relevant to human exposure (mM to sub-nM).

Numerous studies have examined associations between air pollution and pregnancy outcomes but most have been restricted to urban populations living near monitors. The objective of the study was to examine the association between pregnancy outcomes and fine particulate matter in a large national study including urban and rural areas.

Drinking water is recognized as a source of lead (Pb) exposure. However, questions remain about the impact of chronic exposure to lead-contaminated water on internal dose. The objective of the study was to estimate the relation between a cumulative water Pb exposure index (CWLEI) and blood Pb levels (BPb) in children aged 1 to 5 years.

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A limited literature base suggests that ambient temperature contributes to suicide, with studies typically focused on a single nation using temporal and spatial aggregated data. The researchers evaluated an association between ambient temperature and suicide in multiple cities in three East Asian countries.

he health effects of suspended particulate matter (PM) may depend on its chemical composition. Associations between maternal exposure to chemical constituents of PM and newborn’s size have been little examined. The researchers aimed to investigate the associations of exposure to elemental constituents of PM with term low birth weight (LBW, weight

Experimental studies have shown a decrease in driving performance at high temperatures. The epidemiological evidence on the relationship between heat and motor vehicle crashes is not consistent. The objective of the study was to estimate the impact of high ambient temperatures on the daily number of motor vehicle crashes and, in particular, on crashes involving driver performance factors (namely distractions, driver error, fatigue or sleepiness).

Trihalomethanes (THMs) and haloacetic acids (HAAs) are regulated disinfection by-products (DBPs); their joint reproductive toxicity in drinking water is unknown. The researchers aimed to evaluate a drinking water mixture of the four regulated THMs and five regulated HAAs in a multigenerational reproductive toxicity bioassay.

Trihalomethanes (THMs) and haloacetic acids (HAAs) are regulated disinfection by-products (DBPs); their joint reproductive toxicity in drinking water is unknown. The researchers aimed to evaluate a drinking water mixture of the four regulated THMs and five regulated HAAs in a multigenerational reproductive toxicity bioassay.

Both short- and long-term exposures to fine particulate matter (PM2.5) are associated with mortality. However, whether the associations exist below the new EPA standards (12 μg/m3 of annual average PM2.5, 35 μg/m3 daily) is unclear. In addition, it is not clear whether results of previous time series studies (fit in larger cities) and cohort studies (fit in convenience samples) are generalizable to the general population. The objective of the study was to estimate the effects of low-concentration PM2.5 on mortality.

Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. The researchers aimed to investigate the association between air pollution and adult onset asthma.

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