In 2011, WHO member states signed up to the 25 × 25 initiative, a plan to cut mortality due to non-communicable diseases by 25% by 2025. However, socioeconomic factors influencing non-communicable diseases have not been included in the plan. In this study, we aimed to compare the contribution of socioeconomic status to mortality and years-of-life-lost with that of the 25 × 25 conventional risk factors.

Worldwide rise of obesity may be partly related to the relaxation of natural selection in the last few generations. Accumulation of mutations affecting metabolism towards excessive fat deposition is suggested to be a result of less purging selection. Using the WHO and UN data for 159 countries there is a significant correlation (r = 0.60, p<0.01) between an index of the relaxed opportunity for selection (Biological State Index) and prevalence of obesity (percentage of individuals with BMI >30kg/m2).

Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of developing type 2 diabetes, cardiovascular disease and related metabolic and inflammatory disturbances. Although the mechanisms linking adiposity to associated clinical conditions are poorly understood, recent studies suggest that adiposity may influence DNA methylation, a key regulator of gene expression and molecular phenotype.

Previous studies identified associations between maternal obesity and childhood neurodevelopment, but few examined paternal obesity despite potentially distinct genetic/epigenetic effects related to developmental programming.

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Dietary intake of added sugars has increased dramatically worldwide during the past few decades, coinciding with increases in obesity and noncommunicable diseases. About 75% of all processed foods and beverages contain added sugar in the United States.

Tackling the overconsumption of discretionary foods (foods and drinks not necessary to provide the nutrients the body needs) is central to aligning human and planetary health. Whilst the adverse health impacts of discretionary foods are well documented, the environmental and broader sustainability impacts of these products deserve more attention, especially since their consumption has been increasing in recent decades, particularly amongst low income groups.

Long-term fine particulate matter (PM2.5) exposure is linked with cardiovascular disease, and disadvantaged status may increase susceptibility to air pollution-related health effects. In addition, there are concerns that this association may be partially explained by confounding by socioeconomic status (SES).

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