An accurate early warning system to predict impending epidemics enhances the effectiveness of preventive measures against dengue fever. The aim of this study was to develop and validate a forecasting model that could predict dengue cases and provide timely early warning in Singapore.
Open source drug discovery offers potential for developing new and inexpensive drugs to combat diseases that disproportionally affect the poor. The concept borrows two principle aspects from open source computing (i.e., collaboration and open access) and applies them to pharmaceutical innovation. By opening a project to external contributors, its research capacity may increase significantly. To date there are only a handful of open source R&D projects focusing on neglected diseases.
Dengue virus belongs to family Flaviviridae, having four serotypes that spread by the bite of infected Aedes mosquitoes. It causes a wide spectrum of illness from mild asymptomatic illness to severe fatal dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS). Approximately 2.5 billion people live in dengue-risk regions with about 100 million new cases each year worldwide. The cumulative dengue diseases burden has attained an unprecedented proportion in recent times with sharp increase in the size of human population at risk.
WHO panel proposed treaty requires all governments to share cost
India supports a proposed legally binding global instrument that requires all governments to share the cost of research and development (R&D). The treaty, recommended by a World Health Organisation panel, will boost access to countries least able to pay for medical innovations but need it most. This would also delink profits from medical discoveries.
Dengue is the most important mosquito-borne, human viral disease in many tropical and sub-tropical areas. In India the disease has been essentially described in the form of case series. We reviewed the epidemiology of dengue in India to improve understanding of its evolution in the last 50 years and support the development of effective local prevention and control measures.
Health is a crucially important social and economic asset - a cornerstone for human development. Three of the eight Millennium Development Goals (MDGs) call for specific health improvements by 2015: reducing the child and maternal mortality and slowing the spread of HIV/AIDS, malaria and tuberculosis.
Malaria is an ancient disease in India. Known as the ‘king of diseases’, malaria was estimated to cause 75 million cases and 0.8 million deaths annually. In epidemic years, morbidity and mortality used to increase 2–3 times. Ravages of malaria were so rampant and devastating, that the economic growth of the country remained paralysed.
Dengue is one of the most important mosquito-borne viral diseases in the world, and is endemic in approximately 120 countries. It has been estimated that there are 50–100 million cases of dengue fever and 3.6 billion people are at risk of infection. It is emerging and re-emerging in the tropics and currently poses the most significant arboviral threat to humans.
The objective of this study was to investigate the use of novel surveillance tools in a malaria endemic region where prevalence information is limited. Specifically, online reporting for participatory epidemiology was used to gather information about malaria spread directly from the public. Individuals in India were incentivized to self-report their recent experience with malaria by micro-monetary payments.
