In 1996, the global HIV community gathered in Vancouver, Canada, for the XI International AIDS Conference and shared the clear evidence that triplecombination antiretroviral treatment held the power to stem the tide of deaths from AIDS. The HIV treatment era had begun. As we gathered again in Vancouver in July, 2015, it was clear that a new transformative moment is upon us.

The study investigated exposure to individual environmental chemicals and selected mixtures in relation to the presence of antinuclear antibodies (ANA), a widely used biomarker of autoimmunity, in a representative sample of the U.S. population.

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Bangladesh is one of the most vulnerable countries to climate change. People are getting educated at different levels on how to deal with potential impacts. One such educational mode was the preparation of a school manual, for high school students on climate change and health protection endorsed by the National Curriculum and Textbook Board, which is based on a 2008 World Health Organization manual. The objective of this study was to test the effectiveness of the manual in increasing the knowledge level of the school children about climate change and health adaptation.

An analysis of observed trends in African annual-average near-surface temperatures over the last five decades reveals drastic increases, particularly over parts of the subtropics and central tropical Africa. Over these regions, temperatures have been rising at more than twice the global rate of temperature increase.

The climate of the past millennium provides a baseline for understanding the background of natural climate variability upon which current anthropogenic changes are superimposed. As this period also contains high data density from proxy sources (e.g. ice cores, stalagmites, corals, tree rings, and sediments), it provides a unique opportunity for understanding both global and regional-scale climate responses to natural forcing.

The objective of the study was to investigate the association between use of combined oral contraceptives and risk of venous thromboembolism, taking the type of progestogen into account.

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Large earthquakes are thought to release strain on previously locked faults. However, the details of how earthquakes are initiated, grow and terminate in relation to pre-seismically locked and creeping patches is unclear1, 2, 3, 4. The 2015 Mw 7.8 Gorkha, Nepal earthquake occurred close to Kathmandu in a region where the prior pattern of fault locking is well documented5. Here we analyse this event using seismological records measured at teleseismic distances and Synthetic Aperture Radar imagery.

Large earthquakes are thought to release strain on previously locked faults. However, the details of how earthquakes are initiated, grow and terminate in relation to pre-seismically locked and creeping patches is unclear. The 2015 Mw 7.8 Gorkha, Nepal earthquake occurred close to Kathmandu in a region where the prior pattern of fault locking is well documented. Here we analyse this event using seismological records measured at teleseismic distances and Synthetic Aperture Radar imagery.

The latest Ebola virus (EBOV) epidemic spread rapidly through Guinea, Sierra Leone, and Liberia, creating a global public health crisis and accelerating the assessment of experimental therapeutics and vaccines in clinical trials. One of those vaccines is based on recombinant vesicular stomatitis virus expressing the EBOV glycoprotein (VSV-EBOV), a live-attenuated vector with marked preclinical efficacy. Here, we provide the preclinical proof that VSV-EBOV completely protects macaques against lethal challenge with the West African EBOV-Makona strain.

Detailed geodetic imaging of earthquake rupture enhances our understanding of earthquake physics and induced ground shaking. The April 25, 2015 Mw 7.8 Gorkha, Nepal earthquake is the first example of a large continental megathrust rupture beneath a high-rate (5 Hz) GPS network. We use GPS and InSAR data to model the earthquake rupture as a slip pulse of ~20 km width, ~6 s duration, and with peak sliding velocity of 1.1 m/s that propagated toward Kathmandu basin at ~3.3 km/s over ~140 km.