Recent in vitro and animal studies have found the proton pump inhibitor (PPI) lansoprazole to be highly active against Mycobacterium tuberculosis. Omeprazole and pantoprazole have no activity. There is no evidence that, in clinical practice, lansoprazole can treat or prevent incident tuberculosis (TB) disease.

Original Source

Self-rated health (SRH) accounts comprehensively for many health domains. The aim of this paper was to investigate time trends and associations between age-comparative self-rated health and some known determinants in a general population aged 24–34 years. Population-based cross-sectional surveys were performed in 1990, 1994, 1999, 2004, 2009 and 2014 in Northern Sweden.

Original Source

Most climate change mitigation scenarios that are consistent with the 1.5–2 °C target rely on a large-scale contribution from biomass, including advanced (second-generation) biofuels. However, land-based biofuel production has been associated with substantial land-use change emissions. Previous studies show a wide range of emission factors, often hiding the influence of spatial heterogeneity. Here we introduce a spatially explicit method for assessing the supply of advanced biofuels at different emission factors and present the results as emission curves.

Mesoscale convective system (MCS)-organized convective storms with a size of ~100 km have increased in frequency and intensity in the USA over the past 35 years, causing fatalities and economic losses. However, their poor representation in traditional climate models hampers the understanding of their change in the future. Here, a North American-scale convection-permitting model which is able to realistically simulate MSCs is used to investigate their change by the end-of-century under RCP8.5.

The existence and magnitude of the recently suggested global warming hiatus, or slowdown, have been strongly debated. Although various physical processes have been examined to elucidate this phenomenon, the accuracy and completeness of observational data that comprise global average surface air temperature (SAT) datasets is a concern9,10. In particular, these datasets lack either complete geographic coverage or in situ observations over the Arctic, owing to the sparse observational network in this area.

Residential solid biomass cookstoves are important sources of aerosol emissions in India. Cookstove emissions rates are largely based on laboratory experiments conducted using the standard water-boiling test, but real-world emissions are often higher owing to different stove designs, fuels, and cooking methods. Constraining mass emissions factors (EFs) for prevalent cookstoves is important because they serve as inputs to bottom-up emissions inventories used to evaluate health and climate impacts.

Adapting international guidelines to suit local context can drive evidence based practice in low and middle income countries, say Abha Mehndiratta and colleagues, as they describe a pragmatic approach to develop standard treatment guidelines for India.

Original Source

Air pollution exposure is the second most important risk factor for ill health in South Asia, contributing to between 13% and 21.7% of all deaths and approximately 58 million disability adjusted life years (DALYs) through chronic and acute respiratory and cardiovascular illnesses.1 Of the top 30 cities in the world with the poorest air quality in 2016, 17 are in South Asia.2 The impact of air pollution transcends boundaries. The “brown cloud”—caused by pollution from carbon aerosols—is a phenomenon captured in satellite images of atmospheric haze over South Asia, as well as China.

Coral reefs are among Earth’s best-studied ecosystems, yet the degree to which large predators influence the ecology of coral reefs remains an open and contentious question. Recent studies indicate the consumptive effects of large reef predators are too diffuse to elicit trophic cascades. Here, we provide evidence that such predators can produce non-consumptive (fear) effects that flow through herbivores to shape the distribution of seaweed on a coral reef.

Original Source

Empirical two-part models describe the relationship between conservation spending, human development pressures and biodiversity loss and can inform sustainable development strategies by predicting the effects of financing decisions on future biodiversity losses.