Octopods have successfully colonised the world’s oceans from the tropics to the poles. Yet, successful persistence in these habitats has required adaptations of their advanced physiological apparatus to compensate impaired oxygen supply. Their oxygen transporter haemocyanin plays a major role in cold tolerance and accordingly has undergone functional modifications to sustain oxygen release at sub-zero temperatures. However, it remains unknown how molecular properties evolved to explain the observed functional adaptations.

The efficacy and safety of the RTS,S/AS01 candidate malaria vaccine during 18 months of follow-up have been published previously. Herein, we report the final results from the same trial, including the efficacy of a booster dose.

The process of managing the blood bag that is received from the blood donation events needs a proper and systematic management. The blood bag must be handled with care and treated thoroughly as it is related to someone's life. The development of Web-based Blood Bank Management System (BBMS) is proposed to provide a management functional to the blood bank in order to handle the blood bag. In Kuala Terengganu, East Peninsular Coast of Malaysia has only one government hospital that handles blood bank currently is using a standalone system.

Improving environmental adaptation in crops is essential for food security under global change, but phenotyping adaptive traits remains a major bottleneck. If associations between single-nucleotide polymorphism (SNP) alleles and environment of origin in crop landraces reflect adaptation, then these could be used to predict phenotypic variation for adaptive traits. We tested this proposition in the global food crop Sorghum bicolor, characterizing 1943 georeferenced landraces at 404,627 SNPs and quantifying allelic associations with bioclimatic and soil gradients.

After several tsunami events with disastrous consequences around the world, coastal countries have realized the need to be prepared to minimize human mortality and damage to coastal infrastructures, livelihoods and resources. The international scientific community is striving to develop and validate methodologies for tsunami hazard and vulnerability and risk assessments. The vulnerability of coastal communities is usually assessed through the definition of sets of indicators based on previous literature and/or post-tsunami reports, as well as on the available data for the study site.

The research and development costs of 68 randomly selected new drugs were obtained from a survey of 10 pharmaceutical firms. These data were used to estimate the average pre-tax cost of new drug development. The costs of compounds abandoned during testing were linked to the costs of compounds that obtained marketing approval. The estimated average out-of-pocket cost per new drug is US$ 403 million (2000 dollars). Capitalizing out-of-pocket costs to the point of marketing approval at a real discount rate of 11% yields a total pre-approval cost estimate of US$ 802 million (2000 dollars).

The vulnerabilities and health burdens of climate change fall disproportionately upon lower income communities and communities of color. Yet the very groups who are most affected by climate change impacts are least likely to be involved in climate adaptation discussions. These communities face critical barriers to involvement including historical disenfranchisement, as well as a sense that climate change is distant and not personally relevant.

Tobacco products differ in their relative health harms. The need for educating consumers about such harms is growing as different tobacco products enter the marketplace and as the FDA moves to regulate and educate the public about different products. However, little is known about the patterns of the public’s knowledge of relative harms.

Original Source

Tropical forests provide global climate regulation ecosystem services and their clearing is a significant source of anthropogenic greenhouse gas (GHG) emissions and resultant radiative forcing of climate change. However, consensus on pan-tropical forest carbon dynamics is lacking. The researchers present a new estimate that employs recommended good practices to quantify gross tropical forest aboveground carbon (AGC) loss from 2000 to 2012 through the integration of Landsat-derived tree canopy cover, height, intactness and forest cover loss and GLAS-lidar derived forest biomass.

A regional analysis of flood risk was carried out in the mountainous area surrounding the city of Bogotá (Colombia). Vulnerability at regional level was assessed and combined with an existing flood susceptibility indicator, thus providing an index that allows the watersheds to be prioritised. Results show that vulnerability can be expressed in terms of four constituent indicators and a sensitivity analysis shows that the classification of vulnerability is robust.