Drugs that are already clinically approved or experimentally tested for conditions other than cancer, but are found to possess previously unrecognized cytotoxicity towards malignant cells, may serve as ftting anti-cancer candidates. Methyl N-(6-phenylsulfanyl-1H benzimidazol-2-yl) carbamate [Fenbendazole, FZ], a benzimidazole compound, is a safe and inexpensive anthelmintic drug possessing an efcient anti-proliferative activity. In our earlier work, we reported a potent growth-inhibitory activity of FZ caused partially by impairment of proteasomal function.

Land change is a cause and consequence of global environmental change. Changes in land use and land cover considerably alter the Earth’s energy balance and biogeochemical cycles, which contributes to climate change and—in turn—affects land surface properties and the provision of ecosystem services. However, quantification of global land change is lacking. Here we analyse 35 years’ worth of satellite data and provide a comprehensive record of global land-change dynamics during the period 1982–2016.

Nitrogen (N) fertilizer represents a significant cost for the grower and may also have environmental impacts through nitrate leaching and N2O (a greenhouse gas) emissions associated with denitrification. The objectives of this study were to quantify the genetic variability in N-use efficiency (NUE) in Indian spring wheat cul

To provide a picture of hydrological impact of climate change across different climatic zones in Europe, this study considers eight river basins: Tagus in Iberian Peninsula; Emån and Lule in Scandinavia; Rhine, Danube and Teteriv in Central and Eastern Europe; Tay on the island of Great Britain and Northern Dvina in North-Eastern Europe.

Original Source

This paper presents future climate and runoff projections for the South Asia region under the RCP8.5 scenario with climate change informed by 42 CMIP5 GCMs. Runoff is projected for 0.5° grids using hydrological models with future climate inputs obtained by empirically scaling the historical climate series.

Original Source

The carbon and water cycles play an important role in ecosystem functioning and are linked to each other through different physical and biological processes. The hydroclimatic disturbances such as droughts affect both hydrological as well as the ecological processes.

Biological soil crusts (biocrusts) are predicted to be sensitive to the increased temperature and altered precipitation associated with climate change. We assessed the effects of these factors on soil carbon dioxide (CO2) balance in biocrusted soils using a sequence of manipulations over a 9-year period. We warmed biocrusted soils by 2 and, later, by 4 ◦C to better capture updated forecasts of future temperature at a site on the Colorado Plateau, USA.

Human-induced environmental and climate change are widely blamed for causing rapid global biodiversity loss, but direct estimation of the proportion of biodiversity lost at local or regional scales are still infrequent. This prevents us from quantifying the main and interactive effects of anthropogenic environmental and climate change on species loss.

This study examines the expected mitigation of greenhouse gases (GHG) and black carbon (BC) emissions associated to the transition from traditional biomass to clean fuels and clean woodburning cookstoves (CCS) in the Mexican residential sector for the period 2014-2030. We developed a spatial-explicit model at a county-level to understand the GHG trade-offs associated to different spatial-temporal CCS and clean fuels dissemination strategies. A business as usual (BAU) and three alternative scenarios with different targets for CCS and LPG dissemination were constructed.

The tropical cyclone Dineo made landfall over southern Mozambique on 15 February 2017. It weakened to a remnant low on 17 February, which hit Botswana on the same day and triggered heavy rainfall that resulted in flooding over the country. This study assesses the performance of the National Centers for Environmental Prediction Global Forecast System (GFS) and the European Center for Medium-Range Weather Forecast (ECMWF) models in forecasting the locations and intensity of the tropical cyclone and its remnant low, the associated cloud cover and rainfall over Botswana.